Karen Blessing Selected Research

Sorbitol (Yal)

2/2014	Novel transgenic mouse models develop retinal changes associated with early diabetic retinopathy similar to those observed in rats with diabetes mellitus.
8/2012	Osmotic stress, not aldose reductase activity, directly induces growth factors and MAPK signaling changes during sugar cataract formation.
6/2011	Efficacy of structurally diverse aldose reductase inhibitors on experimental periodontitis in rats.
4/2011	Orally active multi-functional antioxidants delay cataract formation in streptozotocin (type 1) diabetic and gamma-irradiated rats.
5/2010	Effect of an aldose reductase inhibitor on alveolar bone loss associated with periodontitis in diabetic rats.
8/2004	Anticataract activity of analogs of a sorbitol dehydrogenase inhibitor.

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Karen Blessing Research Topics

Disease

7	Cataract (Cataracts) 09/2014 - 08/2004
4	Diabetic Retinopathy (Retinopathy, Diabetic) 02/2014 - 02/2007
2	Hyperglycemia 01/2012 - 08/2004
2	Alveolar Bone Loss 06/2011 - 05/2010
2	Periodontitis 06/2011 - 05/2010
1	Nephrogenic Fibrosing Dermopathy 05/2015
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2015
1	Alzheimer Disease (Alzheimer's Disease) 01/2015
1	Macular Degeneration (Age-Related Maculopathy) 01/2015
1	Dry Eye Syndromes (Dry Eye Syndrome) 09/2014
1	Diabetes Mellitus 02/2014
1	Infections 05/2010
1	Corneal Edema 04/2007
1	Retinal Neovascularization 04/2007
1	Mydriasis 04/2007
1	Galactosemias (Galactosemia) 06/2002
1	Microaneurysm 06/2002

Drug/Important Bio-Agent (IBA)

9	Aldehyde Reductase (Aldose Reductase)IBA 02/2014 - 06/2002
6	Sorbitol (Yal)FDA Link 02/2014 - 08/2004
6	SugarsIBA 08/2012 - 08/2004
5	Streptozocin (Streptozotocin)FDA Link 09/2014 - 08/2004
5	Retinaldehyde (Retinal)IBA 02/2014 - 06/2002
5	Galactose (Galactopyranose)FDA LinkGeneric 04/2007 - 06/2002
3	imirestatIBA 06/2011 - 05/2010
2	AntioxidantsIBA 01/2015 - 04/2011
2	LipopolysaccharidesIBA 06/2011 - 05/2010
1	GadoliniumIBA 05/2015
1	Contrast MediaIBA 05/2015
1	Amyloid (Amyloid Fibrils)IBA 01/2015
1	MetalsIBA 01/2015
1	Scopolamine (Hyoscine)FDA Link 09/2014
1	Green Fluorescent ProteinsIBA 02/2014
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 08/2012
1	GalactitolIBA 08/2012
1	tolrestatIBA 06/2011
1	QuercetinIBA 06/2011
1	Free RadicalsIBA 04/2011
1	Xylose (D-Xylose)FDA Link 04/2011
1	ProdrugsIBA 04/2007
1	SuspensionsIBA 04/2007
1	Pharmaceutical PreparationsIBA 04/2007
1	fosbretabulin (combretastatin A4)IBA 04/2007
1	L-Iditol 2-Dehydrogenase (L Iditol 2 Dehydrogenase)IBA 08/2004
1	polyolIBA 08/2004

Therapy/Procedure

3	Injections 09/2014 - 05/2010
3	Slit Lamp 09/2014 - 10/2006
2	Therapeutics 04/2011 - 05/2010
1	Intraocular Injections 04/2007
1	Topical Administration 10/2006
1	Oral Administration 08/2004